Components of the organ or disease panels may be ordered individually. ![]() When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient. Monitor disease progression and response to treatment in patients with confirmed PNH ![]() Thrombosis at unusual sites or with unexplained hemolytic anemia or cytopeniaĮvidence of bone marrow failure (aplastic anemia, hypoplastic anemia, MDS) Unexplained hemolysis with iron deficiency, abdominal pain, thrombosis, dysphagia, or granulocytopenia/thrombocytopeniaĬoombs-negative hemolytic anemia that cannot be otherwise explained PNH, CD59, FLAER, CD24, CD15, CD14, CD64, PI-Linked Antigens.ĭiagnose PNH in patients with the following clinical indications: Hematopathology Division-Flow Cytometry Section. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. The GPI-APs have various roles, some of which to help to prevent RBC destruction, fight infection, and promote thrombosis CD markers (CD14, CD16, CD24, and CD59) are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Stem cells develop into RBCs, WBCs, platelets, and other mature cells that contain the mutated PIG-A gene, and as a result, lack sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Paroxysmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. ![]() Sample delivered to Hematopathology lab and are stored at 2-8C up to 72 hours The minimum volume required is 90% of the stated volume Routine venipuncture Collect in EDTA (lavender tube). Paroxysmal Nocturnal Hemoglobinuria (PNH), High Sensitivity, RBC and WBC
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